Defining plasma dose for potential future cancer treatments
Plasma-activated medium for cancer treatment. Credit: He Cheng, Jingyi Luo, Ke Song, Feng Zhao, Dawei Liu, Lanlan Nie, and Xinpei Lu

A new approach to treating cancer may have been found by Chinese researchers, who may have found a way to induce the death of cancer cells without causing any harm to normal cells.

There is always a dose-effect relationship when it comes to the treatment of PAM. Many researchers define the dose as either the treatment time or the power deposited to the surface.

The equivalent total oxidation potential (ETOP) can be used by the scientists to show the relationship between different cell types. The oxidation potential of oxygen and nitrogen species is used to create ETOP.

The power deposited to the surface and the treatment time are not the right choices to define the dose. The important part of the treatment is the delivery of the reactive species. This reactive species concentration is what determines the definition of the plasma dose.

The goal of plasma medicine is to exploit a differentiated interaction of specific plasma components with specific elements or functions of living cells to control and normalizing therapeutic effects. The path from the laboratory bench to the bedside has a critical constraint on it.

Lu said that the determination of plasma dose is important for clinical applications. ETOP may be a well-defined strategy to evaluate its effects because it provides the basis for significant lethality differences between normal and cancer cells.

The contribution of the Plasma's to the biological effect should be represented by a dose. This dose is usually measured by compounds in medicine.

There is a broad spectrum of biological effects, but there are two questions that need to be answered. The elements are integrated into the dose. We don't know how to study the relationship between dose and effect.

ETOP is trying to answer some questions. It was not clear if ETOP was applicable for PAM after the previous study. The applicability of ETOP or PAM should be further studied.

The fit between experimental data and ETOP was found through data analysis. The suggestion is that ETOP is suitable for PAM. The lethality difference between normal and cancer cells can be maximized by using ETOP. The published literature shows that ETOP may provide a strategy to evaluate the selectivity of PAM treatment on different cell types.

The article deals with the effects of the dose of the medicine on the cells.

More information: On the dose of plasma medicine: Plasma-activated medium (PAM) and its effect on cell viability, Physics of Plasmas (2022). DOI: 10.1063/5.0089357 Journal information: Physics of Plasmas