The university is Shinshu University.
It has been difficult to commercially produce spider silk in bulk due to their cannibalistic tendencies. Spider silk is attracting attention for its lustrous appearance. Spider silk can be used to prevent the formation of blood clot and has excellent knot strength to endure repetitive loading and unloading. The behavior of native spider silk was studied.
The progress of regenerating medicine depends on the development of cell cultures. In conventional research, many cell culture substrates made of petroleum-derived polymers have been developed, but the development ofProtein-derived cell culture substrates has not made much progress Silkworm silk has been used for thousands of years. Spider-derived silk has been the focus of attention in the last few years. The cell behavior on spider silk is unknown. The researchers aim to investigate the cell adhesion behavior on spider silk.
Experiments with spider silk-like proteins were done in the past. The size of theProtein was close to that of spider silk. It is important to collect spider silk directly from live spiders and observe cell adhesion of natural spider silk if you want to be an expert in biomaterials.
Three types of spider silk were prepared. The live spider thread had to be winded so that it would be oriented in the same way. They found that there was a difference in the shape of the cells between the three different spider silk shapes.
There is still a need to investigate whether there is a difference in cell activity depending on the surface. It will be a new finding if you know that the cell activity is high on a thread or non-woven fabric. The native spider silk is being investigated.
More information: Kenjiro Yazawa et al, Cell Adhesion Behaviors on Spider Silk Fibers, Films, and Nanofibers, Langmuir (2022). DOI: 10.1021/acs.langmuir.2c00818 Journal information: Langmuir Provided by Shinshu University
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