<span class=Sepsis begins with infection by bacteria or a virus. This panoramic ilustration inside a blood vessel shows rod-shaped bacteria, red blood cells and immune cells called leukocytes. Kateryna Kon/Science Photo Library via Getty Images" src="https://s.yimg.com/ny/api/res/1.2/5ITHoMLR0mlvmpe2SeKEUw--/YXBwaWQ9aGlnaGxhbmRlcjt3PTcwNTtoPTI4NTtjZj13ZWJw/https://s.yimg.com/uu/api/res/1.2/3a0J5pCMfX8QBUU92j3BXQ--~B/aD01ODI7dz0xNDQwO2FwcGlkPXl0YWNoeW9u/https://media.zenfs.com/en/the_conversation_us_articles_815/fa8877fc7732c17810f1254b85fcfacb">

Is it possible for a healthy young woman to die from a cold? There are certain telltale signs of a more serious problem that go undetected.

Sepsis is the leading cause of death in hospitalized patients in the United States. sepsis is the leading cause of death in the world. Many of those who survive will never be able to return to work and some will never be able to return to their homes.

At the University of Pittsburgh School of Medicine, we are working to change the way scientists and doctors think about sepsis. We want to spread awareness about how sepsis can start and how it can be difficult to detect.

A better understanding of the communities we all live in could help everyday people and health care workers recognize and stop this deadly disease.

What is sepsis?

Sepsis is a medical emergency that starts with an infectious disease. Your body makes a cascade of chemicals when you detect a bug. An army of immune cells work together to fight the bug.

Your body gets better when this system works well. Sepsis can happen when the system isn't working well.

When your immune cells pivot from fighting the infection to fighting your own tissues and organs, it's when you start to get Sepsis. An autoimmune response is a condition in which the body's immune system is turned on itself. Many people are familiar with chronic autoimmune diseases, but sometimes it can happen in healthy people.

The immune system can cause harm to the heart, lungs, kidneys, or blood cells. Blood flow to the brain and other organs can be diminished due toInflammation in the blood vessels. A person's blood pressure can become dangerously low if this happens.

Sepsis can cause organ damage and even death if not treated quickly. Mortality from sepsis is expected to jump from 10% to 40% once shock develops.

Infections can cause sepsis. Pneumonia is the most common cause of it. sepsis can be caused by severe COVID-19. Sepsis patients are often seen by a medical professional for infections in the week before their hospitalization. Predicting which infections will lead to sepsis is very difficult.

Treatment options

Prompt recognition of sepsis symptoms is a cornerstone of sepsis treatment. The early signs of sepsis can be missed.

There is no single test that can tell you if you have sepsis. Sepsis symptoms can be similar to other life threatening conditions such as heart attacks, blood clot, bleeding or even an allergic reaction. It is more difficult to diagnose patients with vague and variable symptoms such as weakness and lightheadedness.

A young, otherwise healthy person with pneumonia may look different from an older person with a smoldering skin infection.

Sepsis patients almost always need to be admitted to the hospital or the intensive care unit, and those with severe forms of the disease need to be resuscitated. Support for failing organs may be included in this. In some cases, it is necessary to remove the source of the infections. Death can be caused by delayed sepsis treatment.

Recognizing sepsis before it’s too late

There are differences in the way sepsis is treated. Severe illness isn't a game of chance, according to Covid-19. Sepsis susceptibility and who is most likely to get sick and die is part of a complex interplay of social influences.

Some people are more likely to develop sepsis than other people. Older people with chronic diseases like Obesity and Diabetes have a higher risk of sepsis. Race, poverty, and even driving distance to the hospital may have an effect on who survives sepsis.

The majority of the work done to improve sepsis detection and treatment has been done in hospitals. Doctors, researchers and even government agencies are trying to improve the recognition and treatment of Sepsis. In order to understand an individual's sepsis risk, research has focused on personal health history, social and economic factors, and community features.

There has been little progress in reducing the incidence of sepsis in the U.S. due to these approaches.

New approaches to catching a killer

We are taking a closer look at the role of communities in improving sepsis detection and understanding because of what we know about early sepsis treatment.

When a patient is at home, the early stages of the disease can change quickly. Sepsis cases start outside the hospital, according to scientists. In the days and even hours before a patient is hospitalized for sepsis, it is often in a clinic or emergency medical service setting. Critical treatment windows can mean the difference between life and death.

We are working to improve sepsis care by studying patient symptoms, community factors, diagnosis and treatment patterns outside the hospital. We are working to improve the diagnosis of Sepsis in hospitalized patients. A critical mass of ambulatory clinics and over 40 hospitals will be studied by this coast-to-coast collaboration. We hope that our work will shed light on the early stages of sepsis and explore ways to stop it before it gets out of hand.

We are learning more about the role poverty plays in health outcomes. We are studying how poverty and asthma can work together to increase health outcomes, using a framework called syndemic theory. This framework can change the way we think about sepsis.

The Conversation is a news site that shares ideas from academic experts. It was written by the University of Pittsburgh.

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