Altered gene helps plants absorb more carbon dioxide, produce more useful compounds
Multiple suppressor of tyra2 (sota) mutations rescued the tyra2 growth inhibition and enhanced tyrosine (Tyr) and phenylalanine (Phe) accumulation. (A) A simplified diagram of the shikimate and AAA biosynthetic pathways. DHS, 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase; E4P, erythrose-4-phosphate; PEP, phosphoenolpyruvate; TyrA, TyrA arogenate dehydrogenase. (B) Plant pictures of 4-week-old Col-0 wild-type (WT), tyra2, and two representative sota mutants of Arabidopsis thaliana. The remaining sota mutant plants are shown in fig. S1. (C) Soluble metabolite profiling and shoot area of the 3-week-old Col-0, tyra2, and sota mutants. Dark and light green bars represent that each sota mutant line showed Col-0–like fully mature green leaves and tyra2-like reticulated leaves, respectively. All the metabolic sota mutants exhibited significantly larger shoot area than tyra2 [one-way analysis of variance (ANOVA) with Dunnett's multiple comparisons test, P < 0.001]. Data are means ± SEM (n = 4 independent plant samples). (D) Relative amounts of Tyr and Phe against Col-0 shown in (C) were plotted for metabolic sota (red circles), response sota (blue triangles), and tyra2 (a black square). (E) Plant pictures of representative complementation lines at T2 generation that were generated by introducing either WT DHS (e.g., DHS1WT) or sota-mutated DHS (e.g., DHS1B4) genes, driven by the respective endogenous promoter, into the Arabidopsis tyra2 background. Scale bars, 1 cm. Credit: Science Advances (2022). DOI: 10.1126/sciadv.abo3416

Plants perform miracles on a daily basis. They take carbon dioxide from the air and turn it into chemicals with the help of the sun.

The beginning material for a lot of useful medications, such as aspirin and morphine, are some of the aromatic compounds. Many of the chemicals come from fossil fuels because it is hard to get enough plants to make enough of them. Our bodies can't make others, so they can only be obtained through our food.

Scientists at the University of Wisconsin–Madison have found a way to release the brakes on plants' production of aromatic amino acids. The genetic change caused the plants to absorb more carbon dioxide than they normally would.

If scientists could add a trait like this to crops, it would help them produce more chemicals and reduce greenhouse gases.

One of the major plant pathways that transform carbon into food, fuel, and materials is the aromatic amino acid pathway. For the first time, we have found a way to regulate the key control knob plants use to turn up production.

The findings of Maeda and his team were published in Science Advances.

Plants normally build in natural brakes to the process of making aromatic amino acids. The whole system grinds to a halt when plants are able to produce enough.

The model plant Arabidopsis has been found to have less sensitive brakes due to the fact that the plant's genes have been altered. The plant doesn't know when to stop and keep making these compounds.

The scientists were surprised to find that the plants took in more carbon dioxide to fuel their growth.

Increased photosynthesis does two things. Adding more energy to operate this pathway is one way to do that. More carbon building blocks are needed to make aromatic chemicals.

Lignin is an energy dense compound that can be found in the cell wall.

There is a small mustard plant. The model in the lab isn't worth anything. The co-author of the book wants to test the same changes in crops and plants that take in a lot of carbon dioxide.

The brakes we identified are very similar to plants. "Expanding this discovery to crops opens up a lot of possibilities, such as enriching our food with essential nutrients or improving bioenergy production, while capturing more carbon dioxide from atmosphere to slow down the global warming."

More information: Ryo Yokoyama et al, Point mutations that boost aromatic amino acid production and CO2 assimilation in plants, Science Advances (2022). DOI: 10.1126/sciadv.abo3416 Journal information: Science Advances