One of the main theories for the cause of Alzheimer's disease is that the brain's waste removal system is malfunctioning.
According to a statement about the NYU study, the researchers behind this fascinating new paper, published as the cover article in the journal Nature Neuroscience, are arguing that the roots of Alzheimer's may begin forming much earlier than previously thought.
Neuroscience researchers believe that the cause of the disease is due to the brain cell's waste removal sacs. These sacs are essential to the breakdown, removal, and recycling of metabolic waste from everyday cell reactions, as well as to removing disease from brain cells.
The researchers found that some lysosomes became enlarged when they fused with the waste they were supposed to remove.
The amyloid plaque that is a hallmark of Alzheimer's appeared inside these poisoned flowers much sooner than before.
The working hypothesis was that the damage seen in Alzheimer's disease was caused by the amyloid build up outside of brain cells.
New evidence changes our understanding of how Alzheimer's disease progresses.
It explains why many experimental therapies designed to remove amyloid plaques have failed to stop disease progression because the brain cells are already crippled before the plaques fully form outside the cell.
While studies on mice brain cells aren't going to upend decades of research on their own, these findings lay the groundwork for replicating and larger studies that could lead to better-honed Alzheimer's medications and treatments in the future.
The root cause of Alzheimer's is thought to affect six million people in the US, and finding the culprit could be a big deal.
There is evidence for the origin of Alzheimer's disease plaques.
Alzheimer's may be caused by cell phones.
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