Between now and the end of June, nearly 200 flights have been canceled by Tui Airways due to the chaos caused by the UK's summer travel season.
The airline made the announcement after passengers had long delays due to staff shortages.
Six daily flights will be canceled up to June 30.
Passengers are being forced to wait in long lines at airports because of the axed flights.
The situation is getting worse this week due to the rise in demand caused by the half-term school holiday and the Platinum Jubilee bank holiday.
Thousands of people were allowed to go during the coronaviruses epidemic, causing staff shortages in the aviation industry.
Government travel restrictions suppressed demand as airlines and airports called for more financial support.
They are having a hard time recruiting new workers and getting their security checks done.
Louise Haigh accused the Government of being missing in action.
She said that tory ministers couldn't even get the basics right.
They should show some responsibility, do their job, and take concrete steps to tackle the chaos growing on their watch.
Legislation was introduced last month by the Transport Secretary to allow new aviation recruits to start training before passing security checks.
An extremely high number of people travelling this week has caused airports to bebusier than usual.
The aviation industry is responsible for making sure they have enough staff to meet demand and we have been clear that they must step up recruitment to make sure disruption is kept to a minimum.
We have changed the law to give the sector more flexibility when training new employees, which will help it to fill vacancies more quickly.
We have worked with Border Force to make sure preparations meet passenger demand.
Between May 25 and Tuesday, the firm said, 291 departures from major UK airports have been canceled.
Due to ongoing challenges in our operation, we have had to announce a small number of planned cancellation between now and 30 June from Manchester Airport only.
All impacted customers will receive a full refund after we contact them directly.
We can assure our customers that the rest of the flying programme will go on as planned.
In response, the airport said the carrier and its ground handler, Swissport, are suffering from staff shortages and experiencing significant challenges with their check-in and baggage reclaim operations.
We are obviously disappointed to see passengers plans disrupted in this way, but we understand the difficult decision to cancel a number of services over the course of the next month.
At least 31 flights were canceled by EasyJet on Tuesday.
British Airways said passengers are being told several days in advance of flights being canceled.
People are reporting delays at airports.
The passenger described the terminal as a mess with a long queue for security.
A queue at Manchester Airport stretched along a car park, described by a user as "madness".
A passenger at the airport said travellers were waiting for three hours to get their luggage.
People have abandoned them. We were told to come back during the week.
A passenger on a flight from Gatwick had to wait for four and a half hours to check in.
He wrote that it was the worst airport experience ever.
Sharon Graham said those in charge of UK aviation companies should hang their heads in shame.
They got rich on high profits and low pay. They slashed the wages of thousands of workers during the Pandemic. They are reaping what they have sown because people don't want to work for them anymore.
There are staff shortages across the industry and huge reliance on overtime to get by, according to the deputy general secretary of the Prospect union.
Things could get worse this summer before they improve.