Up to 150,000 fans will be in Spain for the final of the Europa League.
Rangers supporters were expected to outnumber Eintracht Frankfurt fans by two to one.
The capacity of the stadium is just 42,700.
The trains heading to the city from Madrid and Malaga were completely full with the same expected on Wednesday.
The road leading to the stadium where the game is being held is shutting down on Tuesday and a security perimeter will be put in place on the day of the game.
Extra bus services will be added on the day of the game to take ticketless Rangers fans to the stadium in the north of the city where the match is being shown on a big screen.
Fans without tickets will be able to watch the game on a big screen.
The event will be attended by 5,000 police officers.
Celtic lost the 2003 Uefa Cup final to Porto in the same stadium where Uefa allocated just 9,500 tickets to the fans of the two clubs.
The sponsors and people from other clubs received the rest of the tickets.
There will still be tens of thousands of fans without tickets, even if more tickets are available.
Despite the large number of visitors, city officials insist that Seville is ready to host the final.
It has put in place a special cleaning plan that involves 200 workers washing down the pavement and emptying litter bins.
The busiest areas of the city have been home to over 100 urinals.
Violence has marred the previous two European finals involving Rangers.
Rangers were banned from European competition for a year after fans clashed with Spanish police at the end of their 1972 European Cup Winners' Cup final victory.
There were violent scenes in Manchester city centre in 2008 after an estimated 200,000 fans travelled south ahead of the Uefa Cup final.
Thirty-nine police officers were injured during the trouble and a Crown Court judge later described it as the worst night of violence and destruction in Manchester city centre since the 1960s.
The mayor of Seville said the city was ready to welcome the fans of both teams.
The city was expecting a capacity crowd for the game, along with many more fans from both Scotland and Germany, according to Antonio Mu.
The mayor hoped fans would enjoy their time in the city.
He said there would be two screens for fans without tickets.
Rangers fans have begun arriving in the city ahead of the game, with many more due to make the journey using a variety of routes.
The temperature is expected to reach 34C in the days before the match, with the weather expected to be hot this week.
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