Fabinho will not be able to play in the FA Cup final.
The Brazilian was forced off in the first half of the game with a muscular injury.
The Quadruple is still a goal of the Reds, as they still hope to have Fabinho back in the next season.
There is a good chance that he will be back whenever.
Next Tuesday, after the FA Cup final, the Reds return to action in the league.
They will play their final league game at home to Wolves on May 22 before they play Real Madrid in the final of the European club competition in Paris on May 28.
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The loss of Fabinho could have far-reaching ramifications beyond the title race. Will he be fit for the final of the competition?
The importance of the Brazilian can be overstated. When covering for those marauding full-backs, a towering figure at the base of the middle of the field is used to protect the defence.
Since the start of the year, Fabinho has only been in the starting line-up on three occasions in the premier league.
He sat out the second leg against Benfica in the second edition of the competition, which was the only time this year that the Reds have conceded three goals. A quick return could be crucial to his team.
The FA Cup final is on May 14.
Sky Sports broadcasts the Premier League.
The Wolves are in the Premier League.
The Real Madrid final is May 28.