Manchester City moved three points clear of their rivals at the top of the league with a win on Sunday.
The race for third place is only one point ahead of second place, while Manchester United and West Ham are fighting for the final spot in the Europa League.
In other games, Crystal Palace beatWatford in a game that confirmed the Hornets's demise, while Bournemouth beat Bournemouth and Brentford beat Saints.
Who made the Team of the Week? You can make your own selections at the bottom of the article.
For the second week in a row, Jordan Pickford saved the team.
The save from Harvey Barnes was quite incredible and the one-handed stop from Nampalys Mendy was almost identical to the save made by Peter Shilton during the England versus Scotland game at Wembley.
Pickford's save againstLeicester was regarded as a world class save, and this shows how good it was.
Did you know? Jordan Pickford made seven saves against the Foxes, his most in a single match in the league.
When you consider what is happening in Ukraine at the moment with the Russian invasion, it's a testament to Mykolenko's strength, courage and resilience that he's in any fit mental state to play professional football.
It must have raised some eyebrows to have the Ukraine international in the starting line-up.
The goal by the full-back gave the catalyst for the team to go on and win the game and take three vital points.
They have taken six points from their past two games and are back in the driver's seat.
Did you know? Vitaliy Mykolenko is the first Ukrainian to score a goal in the English top flight, becoming the 39th different country to find the net in the competition.
The tackle was brutal and contemptuous. Jordan Henderson felt the weight of the boot of the Spurs defender as he left him on the touchline.
The referee ignored any overtures for a foul. The tackle was brilliant and set the tone for a proper game of football.
The ball was fair and square. The game is not over yet.
Did you know? Dejan Kulusevski made more for either side in the match, as he made 10 ball recoveries.
It is very easy when your position in the league is safe and there is no threat of the league being thrown into turmoil. Wolves have not won a football match in the last four games, and they have had their minds on the Costa del Sol.
I am not entirely sure, but it was a helluva comeback. It might have been the goal that substitute Francisco Trincao scored with minutes left to play which galvanized them, but to see Wolves flood the penalty area, desperate to get an equalizing goal, was a world away from where they have been recently.
When the team was desperate, who else was going to get the goal in open play when the team was not playing well?
Did you know? It was the second-latest ever goal in the premier league, after the one from August 2019. It was the second goal that the Blues have conceded in the last year.
If anyone doubted why I pick goal scorers for my team, they only had to watch the reaction of Cucurella.
The enormity of what it meant to him was obvious. When you score your first goal on a football field, it can be very emotional, because it is the most difficult thing to achieve.
Cucurella will remember his goal against Manchester United for the rest of his life. United will want to forget this encounter as soon as possible.
Did you know? Cucurella scored his first goal for the Seagulls and had the most touches and completed the most passes of any player.
After a performance like that, I am not surprised that Manchester United will not make the playoffs. I don't know what happens to the center-backs at United.
You couldn't blame Harry Maguire for the defeat as he wasn't on the pitch. Raphael Varane was given nightmares by Pascal Gross.
The German has been outstanding all season. Graham Potter is the only person who has been better. The Seagulls are currently ninth in the table and look like they will finish in the top half of the league.
Did you know? Gross has scored four goals against Manchester United, double the amount he has scored against any other side.
I am a huge fan of Philippe Coutinho but the arrival of Emiliano Buendia in the Villa team gave them a spark that may help them stay in the league.
The Clarets have staged a mini revival under Mike Jackson, but they seem to have run out of steam.
They were run ragged by Buendia. If James Tarkowski is not fit in time, then they will have to leave the league and the only player who has held them together is limping off.
Did you know? In his 67th appearance in the competition, Buendia scored and assisted for the first time.
After a bad experience in Madrid, Manchester City were back to their winning ways. Their departure from the European competition did not seem to affect their attempt to win the title.
The cries of "campione, campione" rang out from the City supporters as Kevin de Bruyne was the architect of this commanding performance.
I don't think it will backfire, but the fans will hope it does. The title is over. I think City have to do a lot of things to win the title.
Did you know? Kevin de Bruyne has created 77 chances this season, taking his total to 77. The Belgian has created the most chances per 90 minutes.
Within 45 minutes of the game starting, this match was over. Benrahma was putting more nails in the coffin, not just running the show for West Ham.
Having already been demoted, playing the season out must be very difficult for the players, but they did have a go in the second half. If they want to return to the premier league immediately, they need to start preparing now.
The Hammers recovered well after a difficult Europa League exit. The manager of a team that reaches the European football finals has to keep his head up.
Did you know? Said Benrahma has 21 goal involvements in the competition after scoring his eighth and ninth goals. Since Benrahma's debut in October 2020, only two other players have registered more than 20 goal involvements for the Hammers.
All you need to know about his popularity in the dressing room is the reaction from his team-mates to his successfully converted penalty.
It was the way he stuck away his second goal with such confidence and composure that suggests Thomas Tuchel must be very careful with how he handles the future of Rome.
It has been a difficult season for the Chelsea forward and he could return to Italy in a heartbeat. There is uncertainty surrounding the club at the moment.
The new owners would be wise to stem the flow of departures until they get their feet under the table.
Did you know? Romelu Lukaku is now the top scorer in all of the competition with 14 goals.
Nketiah thinks that it looks like they have found a replacement for Pierre-Emerick. I find it odd that a 22-year-old English forward, who is playing for a club he has always dreamed of playing for, has not had his future decided by the club.
He is a top player. They would be crazy to let Nketiah go even if they were to buy a renowned goal scorer.
They only have themselves to blame for that. Asking goalkeepers to manipulate the ball with their feet is crazy.
I can only imagine how stupid Ayling was when he left his team to play the rest of the game with 10 men. He stays on the field.
Did you know? Eddie Nketiah scored twice in the first 10 minutes of a game for the first time in his career, making him just the second player in the history of the league to score twice in the first 10 minutes.
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Real Madrid were destroyed by Manchester City over two legs, but they are still in the final of the Champions League.
There have been calls for Manchester City's manager to be sacked because of the club's poor performance in the playoffs.
City fans have the right to be angry. They had two great chances to lift the trophy.
When hurt, football fans allow their frustration to get the better of them, but no serious Manchester City fan could possibly contemplate anything so hysterical as showing the door and expecting to be taken seriously.
The way in which City brushed aside Newcastle United in pursuit of another trophy suggests that the suffering that took place in Madrid last Wednesday night was just part of the winning.
Ian Wright painstakingly told me over lunch this week that City hadn't deserved to win the trophy.
In the final, a questionable challenge by Ramos resulted in the injury of Mohamed Salah. The situation was made worse by the goalkeeping errors made by the man.
The Reds have returned to the finals in both of the last two years. Manchester City have not suffered enough to win the trophy. They will when they have.