Liverpool need just five points to guarantee a first top-flight title triumph since 1990.
But when is the earliest that Jurgen Klopp's side can be crowned Premier League champions for the first time?
If Liverpool beat Crystal Palace at home on Wednesday, the Reds will be champions if Pep Guardiola's side fail to win at Chelsea.
You can watch this game on BT Sport, listen on BBC Radio 5 Live and follow live text commentary on the BBC Sport website.
Victories for Liverpool against Palace and Manchester City at Chelsea would leave the Reds needing a point against City at the Etihad to win the league.
You can watch this on Sky Sports and listen to updates on BBC Radio 5 Live, plus live text commentary on the BBC Sport website.